The clinical and pathological information retrieved from patients files included. Radiotherapy if a salivary gland tumour is cancerous, radiation therapy may be necessary fast neutron therapy has been used successfully to treat salivary gland tumors, 11 and has shown to be significantly more effective than photons in studies treating unresectable salivary gland tumors. Salivary gland tumors merck manuals professional edition. Evaluation of cystic salivary gland lesions by fineneedle aspiration. Inflammatory tumors and benign cysts represent the major cause of salivary gland enlargements in children.
Salivary gland tumors, like tumors arising in other tissues, are classed on the basis of the differentiation properties of the tumor cells. Salivary gland cancer is a rare disease in which malignant cancer cells form in the tissues of the salivary glands. Sep 04, 2019 salivary gland tumors sgts are uncommon and represent 24% of head and neck neoplasms. Salivary gland tumors after childhood radiation treatment for benign conditions of the head and neck. Salivary gland tumours most often present as painless enlarging masses. Salivary gland tumors, pleomorphic adenoma, cystic adenoid. Warthins tumor with a pleomorphic adenoma in the same parotid gland, and the other documents. The principal hurdle in their management lies in the difficulty in distinguishing benign from malignant tumours. Kaul concerning head and neck regions, it is known that tumors of the salivary glands correspond on an average to 3% of the affections of this site and the majority being of epithelial origin 1, 2. Here you can find more information on the different types of salivary gland cancers.
Salivary gland tumors account for 68% of headneck tumors parotid glands 80 % of salivary neoplasms submandibular glands. Tumors of minor salivary glands med oral patol oral cir bucal. Minor salivary gland tumors msgts are infrequent, accounting for 1015% of all salivary neoplasms, and are fundamentally located in the palate 50%, lips 15%. Characteristics of 5015 salivary gland neoplasms registered in the. Normal salivary glands are made up of many different kinds of cells, and tumors can start in any of these cell types. Salivary gland cancer statistics american cancer society. The salivary glands are classified as major or minor. Research conducted at the florida campus of the scripps research institute has. For malignant tumors, treatment is with excision and radiation. The following tumor types should not be reported using this protocol. Discussion on the surgical treatment of parotid tumours. Multidisciplinary management of salivary gland cancers. This theory is supported by indirect evidence from light and electron microscopy.
The minor salivary glands consist of 800 small mucussecreting glands located throughout the lining of the oral cavity. For the pathologist, it is this differentiation process and the architectural arrangement of the tumor cells that are the keys to classifying a particular salivary gland tumor. Epidemiological and histopathological patterns of salivary gland. Salivary gland tumors sgt are rare neoplasms that generate interest due to their. Salivary gland tumors are abnormal cells growing in the gland or in the tubes ducts that drain the salivary glands. Histopathological study of salivary gland tumors 88 int j res med. Benign lesions were localized in parotid gland, in 97 95. Cancers that develop here often form tiny mucousfilled cysts. The annual incidence of salivary gland cancers ranges from 0. The major salivary glands consist of the parotid, submandibular, and sublingual glands. There are several pairs of salivary glands in different locations a major pair in front of the ears parotid glands.
Salivary gland tumours or neoplasms are tumours that form in the tissues of salivary glands. Mar 18, 2019 when studied in salivary gland cancer samples and correlated with 5 years of patient followup, high levels of ki67 found in the tumors were strongly correlated with poor survival. The overall incidence of salivary gland tumors varies around the world from approximately 0. Sep 28, 2017 overall, about 72% of people diagnosed with salivary gland cancer are still alive at least 5 years after being diagnosed. Often major salivary glands but also lips, buccal mucosa, palate, tongue, retromolar area, floor of mouth, ectopic salivary glands tumors of palate may erode bone usually indolent behavior but occasionally recurs locally or metastasizes to lymph nodes ear nose throat j 2011.
Types of salivary gland cancer memorial sloan kettering. Salivary glands, ultrasound, ct, mr, education, epidemiology. Following radiotherapy of the head and neck region, salivary gland dysfunction is a predictable sideeffect. Current concepts in diagnosis of unusual salivary gland tumors. Malignant sgts represent 6% of head and neck cancers and 0. Their complexity is attributed to heterogeneity of the cells of. The difficulty distinguishing benign tumors from malignancies is a key management challenge for salivary gland carcinomas, particularly those within the parot id glands. Alternative names tumor salivary duct causes the salivary glands are located around the mouth. Synchronous salivary gland tumors with regard to two cases. In an attempt to explain the histogenesis of salivary gland tumors, a bicellular theory of origin has been presented. This includes people with all types and stages of salivary gland cancer, but the outlook for some people might be better or worse than this. Salivary gland tumors, meningiomas, and schwannomas are the only benign tumors that will survive heterologous intraocular trans fer. Case report an unusual warthins tumor arising from minor salivary.
Jul 28, 2014 genetic mutations linked to salivary gland tumors date. The majority of these neoplasms are benign 80% and only 20% are malignant. More than 30 percent of salivary gland cancers are thought to be this type. The various types of salivary gland tumors are best distinguished by their histologic patterns. Retrospective study of 124 cases of salivary gland tumors and. No tumor was implicated from sublingual mayor salivary gland. Salivary gland tumors sgts are rare neoplasms accounting for 0. Warthin tumor papillary cystadenoma lymphomatosum is a benign salivary gland tumor occurring almost exclusively in. Salivary gland tumors definition salivary gland tumors are abnormal cells growing in the gland or in the tubes ducts that drain the salivary glands. Minor salivary gland tumors are a subtype of salivary gland tumors originating from the minor salivary glands, which are found in the lips, tongue, hard palate, and the mucosa of the oropharynx and larynx, among other locations. Fineneedle aspiration biopsy fnab is a useful preoperative technique for the evaluation of patients with a salivary gland lesion1,2.
Salivary gland tumors are a rare and morphologically diverse group of. Acinic cell carcinoma 3% of all salivary gland neoplasm 8090% in parotid 15% of all parotid tumors mean age is 4050 years 23 occur in female 3% shows bilateral involvement second most common salivary gland tumor in children well circumscribed tumor with fibrosis tissue macroscopically. The parotid gland is the most common site for salivary gland cancer. Risk of salivary gland cancer after childhood cancer. Pathogenesis and histogenesis of salivary gland tumours prezi. Minor salivary gland tumors radiology reference article. Genetic mutations found in rare salivary tumor could improve. Original article histopathological study of salivary gland tumors. In case of a tumor, hemangioma is the most common histotype within the salivary glands in these patients baker and malone 1985.
They commonly present as a painless and slowly evolving neck mass. Msgts account for 15% of all salivary gland tumors. A painless salivary mass is the most common sign and is evaluated by fineneedle aspiration biopsy. Salivary gland cancers malignant salivary gland tumors there are many types of salivary gland cancers. Most salivary gland tumors are benign and occur in the parotid glands. Morphological patterns of salivary gland tumors sindhu sharma, rupali bargotra, k. Any information contained in this pdf file is automatically generated from digital material submitted to.
In 2017, the world health organization reclassified tumors of salivary glands into five broad categories, as follows. Salivary gland neoplasm an overview sciencedirect topics. Build on previous arrocases for salivary gland tumors. Salivary gland tumors are one of the most complex and relatively rare group of lesions encountered in oral pathology practice. Worrisome clinical symp toms eg, pain, hard consistency, rapid tumor growth. Genetic mutations linked to salivary gland tumors sciencedaily. Longterm results are related to the grade of the cancer. Saliva has enzymes that help to digest food and antibodies that help protect against infections of the mouth and thr. For your second question,depending on which mutations are found, you may be eligible for a clinical trial or to be enrolled in a basket trial, which tests a therapy targeting a specific genetic mutation found in the tumor, regardless of where the cancer originated.
Most are located in the parotid glands and most are benign. Tumors of minor salivary glands e583 introduction salivary gland neoplasms represent less than 1% of all tumors, and 35% of all head and neck neoplasms. Worldwide annual incidence of salivary gland tumours varies from 0. Aug 24, 2009 salivary gland neoplasms slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising.
Jun 01, 2015 salivary gland cancer is a rare disease in which cancerous cells form in the tissues of the salivary glands. Salivary gland cancer, adult genetic and rare diseases. Among the 5015 salivary gland neoplasms, 3998 80% were benign and 1017 20% were malignant. Salivary gland tumours are rare and most cases are referred to the head and neck clinic. Msk conducts genomic sequencing only on advanced stage 4 cancers, regardless of cancer type. Investigations such as fine needle aspiration cytology and mri scans provide some useful information, but most cases will require surgical excision as.
The salivary glands make saliva and release it into the mouth. Clinicopathological analysis of salivary gland tumors over a 15year. They produce saliva, which moistens food to help with chewing and swallowing. The problem is compounded by the ability of these cells to differentiate and modify. Salivary gland tumors information mount sinai new york. The majority of these neoplasms are benign and only 20% are malignant. Saliva has enzymes that help digest food and antibodies that help protect against infections of the mouth and throat. Mar 07, 2016 introduction tumors of the salivary glands are. If you continue browsing the site, you agree to the use of cookies on this website. Salivary gland tumors are relatively uncommon and account for approximately 36% of all neoplasms of the head and neck.
Pdf histogenesis of salivary gland neoplasms shaleen. Neoplastic disorders of salivary glands are in general relatively rare and account for 3 to 6% of head and neck tumors. Still in the us, carcinomas of the major salivary glands comprise 11% of oropharyngeal neoplasms. Salivary gland dysfunction refers to either xerostomia the symptom of dry mouth or salivary gland hypofunction reduced production of saliva. Judiciously applied, fnab can assist the clinician in developing a suitable treatment plan. Their complexity is attributed to heterogeneity of the cells of origin of these lesions. The majority of these neoplasms are benign and only 20% are. Pleomorphic adenoma is a lesion which accounts for the vast majority of all salivary tumors pleomorphic adenomas are benign salivary gland tumors, which predominantly affect the superficial lobe. Mucoepidermoid carcinoma is the most common type of salivary gland cancer. The high percentage of vascular tumors reported by many authors exceeds the number of cases registered with the armed. Salivary gland tumors penn state hershey medical center. Salivary gland cancers are named according to which of these cell types they most look like when seen under a microscope.
Minor salivary gland carcinoma consider the lip and oral cavity, nasal. Salivary gland tumors ppt by dr gulzar a bhat authorstream. Histogenesis of salivary gland neoplasms dwivedi n. Differentiation of benign and malignant tumors is not the primary goal of ct and mri. Other markers of cellproliferationlike proteins found in the dna synthesis phase sphase of mitosis, skp2, and cyclin a were correlated with a high ki67 index. Histogenesis of salivary gland neoplasms dwivedi n, agarwal a. Salivary gland tumors tehran university of medical sciences.
140 1265 1039 1274 951 739 288 730 1284 146 988 929 641 1069 1000 1233 665 800 1080 462 1382 1170 784 47 1403 451 829 961 31 1206 1211 1153 1484 779 519 232 478 1028 1411 185 1481 647